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Various CYP isoenzymes likeCYP2D6, CYP3A4, CYP1A2 and othersmetabolise tricylic and related antidepressants.Metabolites are excreted in urine over 1–2weeks.

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The sample size estimate only reflects the contributing assump-tions. Pharmacologic agents, which are in development forvarious clinical syndromes are also discussed.

Q is the actual liver blood flow (l/h), V is themaximum capacity of the metabolizing enzyme (l/h), and Kis the affinity (mg/l).

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